An association among transmembrane protein 108 and bipolar disorder was identified in Han Chinese participants in a genome-wide association study published in JAMA Psychiatry.
Most genome-wide association research have been performed in Europeans. The researchers in the present study sought to determine genome-wide danger loci in Han Chinese.
The researchers recruited 6472 Han Chinese participants from mainland China. A sample of 958 men and women with bipolar disorder and 2050 controls have been incorporated. Genotyping in the discovery stage was performed with either the Illumina Infinium Global Screening Array (GSA) chip or the Illumina Genome-Wide Asian Screening Array (ASA) chip. The imputation reference set was obtained from phase 3 of the 1000 Genomes Project.
Analysis demonstrated that rs9863544 had genome-wide significance (P =2.49 10-8 odds ratio [OR], .650 95% CI, .559-.756). In the GTEx information set, the mRNA of NPHP3-AS1 was barely detectable in most human organs, whereas TMEM108 was “widely expressed” in the human brain.
Based on research in mice, the researchers concluded TMEM108-correlated physiological processes probably contribute to bipolar disorder pathogenesis. However, the Han Chinese genome-wide considerable SNV rs9863544 and its surrounding variations did not show proof of association with bipolar disorder in Europeans, which, the researchers mentioned, suggests a Chinese-particular bipolar disorder danger locus.
Limitations consist of the reality that manage participants have been recruited primarily based on self-reported well being status rather than expert screening.
The authors conclude that their “study describes several novel risk loci for BD and a shared genetic basis for BD across Han Chinese and European populations.” They think that additional investigation is required to more completely fully grasp “the underlying pathological mechanisms.”
Reference
Li HJ, Zhang C, Hui L, et al GeseDNA Research Team. Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: A genome-wide association study and meta-analysis. JAMA Psychiatry. Published on the net December 2, 2020. doi:10.1001/jamapsychiatry.2020.3738
